When Beth Emhoff (Gwyneth Paltrow) returns to Minnesota from a Hong Kong business trip, she attributes the malaise she feels to jet lag. However, two days later, Beth is dead, and doctors tell her husband (Matt Damon) that they have no idea what killed her. Soon, many others start to exhibit the same symptoms, and a worldwide pandemic erupts. Doctors try to contain the lethal microbe, but society begins to collapse as a blogger (Jude Law) fans the flames of paranoia.