Magnificent obsession

Nov 19

2025
with

Dr. Eric Pierce

Ophthalmologist; Molecular Geneticist, Harvard University Ocular Genomics Institute

Magnificent Obsession— Advances in Treatment for Blindness

Before the film, Dr. Eric Pierce, Director of the Harvard Ophthalmology Ocular Genomics Institute, will discuss current therapeutic interventions that are being developed for blindness.

Coolidge Corner Theatre Brookline, MA

Tickets

Film Synopsis

A rich playboy whose recklessness inadvertently causes the death of a prominent doctor tries to make amends to his widow, and falls for her in the process.

    Reckless playboy Bob Merrick (Rock Hudson, in his breakthrough role) crashes his speedboat, requiring emergency attention from the town’s only resuscitator—at the very moment that a beloved local doctor has a heart attack and dies waiting for the lifesaving device. Thus begins one of Douglas Sirk’s most flamboyant master classes in melodrama, a delirious Technicolor mix of the sudsy and the spiritual in which Bob and the doctor’s widow, Helen (Jane Wyman), find themselves inextricably linked amid a series of increasingly wild twists, turns, trials, and tribulations.

    About the Speaker

    Dr. Eric Pierce received his Ph.D. in Biochemistry from the University of Wisconsin-Madison and his M.D. from Harvard Medical School. He did his residency in Ophthalmology at Harvard and fellowship in Pediatric Ophthalmology at Children’s Hospital, Boston where he also took his first faculty position. He was then recruited to the department of Ophthalmology at the University of Pennsylvania School of Medicine, where he was promoted to Associate Professor with tenure. He returned to Harvard in 2011 to establish the Ocular Genomics Institute.

    Dr. Pierce is an ophthalmologist and molecular geneticist whose research program is dedicated to understanding the molecular mechanisms of inherited retinal degenerations (IRDs), and improving therapeutic interventions for these conditions. IRDs are a leading cause of blindness worldwide, and are characterized by progressive dysfunction and death of retinal photoreceptor cells.

    Dr. Pierce’s research program is focused on identifying new IRD disease genes, investigating the mechanism by which mutations in the identified genes lead to blindness, and using this information about disease pathogenesis to develop rational therapies to prevent vision loss.