John Crowley (Brendan Fraser) is a successful advertising executive with a beautiful wife (Keri Russell) and three children. Just as his career is taking off, he learns that his two youngest kids have a rare and fatal genetic disorder. John leaves his job and devotes himself to saving their lives, teaming up with brilliant but eccentric scientist Dr. Robert Stonehill (Harrison Ford). Together they battle the medical and corporate establishment, racing against time for a cure.